Expanding role of the jumonji C domain as an RNA hydroxylase.
نویسندگان
چکیده
JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase.
منابع مشابه
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 285 45 شماره
صفحات -
تاریخ انتشار 2010